Name | GOSSYPIN |
Synonyms | GOSSYPIN ,7-trihydroxy- COTTON CELLULOSE gossypin from hibiscus vitifolius*flowers 3,3',4',5,7-PENTAHYDROXY-8-O-GLUCOSYLFLAVONE 3,3',4',5,7,8-HEXAHYDROXYFLAVONE 8-GLUCOSIDE 2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5,7-trihydroxy-4h-1-b 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5 |
CAS | 652-78-8 |
Molecular Formula | C21H20O13 |
Molar Mass | 480.38 |
Density | 1.883±0.06 g/cm3 (20 ºC 760 Torr) |
Melting Point | 229-230°C |
Boling Point | 886.0±65.0 °C(Predicted) |
Solubility | DMSO: soluble15mg/mL, clear |
Appearance | powder, light yellow to dark green-yellow |
Color | , light yellow to dark green-yellow |
pKa | 5.70±0.40(Predicted) |
Storage Condition | -20°C |
MDL | MFCD00017429 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R62 - Possible risk of impaired fertility R37/38 - Irritating to respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
WGK Germany | 3 |
RTECS | DJ3009900 |
Reference Show more | 1. High core, Wan Yaoyao, Li Changyin, etc. Systematic Analysis of flavonoids in okra based on liquid chromatography-time-of-flight mass spectrometry and mass loss filtration [J]. Analytical Chemistry, 2020. 2. Xiao, Yaqing, et al. "Gel properties and formation mechanism of soy protein isolate gels improved by wheatbrain cellulose." Food chemistry 324 (2020): 126876.https://doi.org/10.1016/j.foodchem.2020.126876 3. [IF = 4.162] Rong Wang et al."Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis."Drug Des Dev Ther. 2021; 15: 2999-3016 |
biological activity | Gossypin is a kind of flavonoids isolated from ISIS vitifolius, which has antioxidant, anti-inflammatory, anti-cancer, anti-aging, anti-diabetic, analgesic and liver protective activity. Gossypin inhibits NF-κB and NF-κB regulated gene expression. Gossypin also inhibited RANKL-induced osteoclast formation in mouse primary bone marrow cells and RAW264.7 cells. |
Target | IC50: NF-Δb |